Immediate tooth replacement therapy has become a mainstream treatment modality for single and multiple tooth implants in the esthetic zone. However, esthetic risks and complications exist such as socket perforation, loss of labial plate thickness over time, and loss of the interdental papilla due to proximity issues with tooth-to-implant distance following placement. Consequently, an inventive macro design concept based upon biologic principles that combines hybrid strategies in implant diameter, shape, and thread pattern has been designed and developed to address these problems. This inverted body-shift design concept will be supported by pre-clinical [animal histology] and clinical [human] studies that scientifically supports, validates, and reinforces the biologic principles in design that ultimately enhances esthetic outcomes in modern day implantology.